NECTAR for strong and/or multifunctional ligands, macromolecules, polyelectrolytes

Strong binding of metal ions (sequestration) and selectivity of binding are processes of outmost importance for several applications (e.g., chelation therapy, nuclear medicine, environmental remediation, metal recovery, water treatment). Strong binding can be operated by a large number of ligands (natural or synthetic) which all share the property of forming very stable complexes. The determination of corresponding thermodynamic equilibrium data is extremely difficult, and cannot be performed by classical approaches. In addition, complexes of some pre-organised ligands (e.g. those currently used in medicine) are formed very slowly, and kinetical aspects have to be considered to get correct thermodynamic data. Also, similar ligands which have limited structural differences often form complexes with the same metal ion that differ in stability by orders of magnitude. Therefore, the design of selective ligands requires a precise knowledge of structure-stability relationships.



Defining recommended experimental procedures and guidelines for the accurate determination of stability constants and other thermodynamic parameters for systems involving natural and synthetic strong chelators, macromolecules, and polyelectrolytes.
Exploring rational or combinatorial strategies, supported by in silico studies, for the design of new ligands for the selective recognition of metal ions or small molecules in solution.


Evaluation of the sequestering ability and selectivity of existing and new chelating agents that are of current interest for the scientific community or for the stakeholders (e.g., metallophores, new generation, complexones, etc.).
Study of the speciation of systems containing structurally complex (macro)molecules (e.g., nucleic acids, peptides and proteins, organic matter, polyelectrolytes).
Cross-evaluation of methods for the study of the thermodynamic selectivity.
Setup of protocols and guidelines for the study of these systems and the determination of their thermodynamic parameters.
Formulation of user-friendly strategies for data analysis, and their dissemination.


Prof Giancarla Alberti - Università degli Studi di Pavia
Prof Liudmil Antonov - Bulgarian Academy of Sciences
Dr Zaneta Arciszewska - University of Bialystok, Faculty of Chemistry
Prof Aculina Aricu - Institute of Chemistry, Academy of Sciences of Moldova
Prof Vladimir Arion - University of Vienna
Dr Paloma Arranz Mascarós - Universidad de Jaén
Dr Sabriye Aydinoglu - Cukurova University
Prof Miquel Barceló Oliver - Universitat de les Illes Balears
Prof Giampaolo Barone - Università degli Studi di Palermo
Dr Nuno Basílio - Faculdade de Ciȇncias - Universidade Nova de Lisboa
Dr Maria Rosa Beccia - Institut de Chimie de Nice
Dr Dana Bejan - "Petru Poni" Institute of Macromolecular Chemistry Iasi
Dr Sanja Belić - University of Novi Sad
Dr Denise Bellotti - University of Ferrara
Prof Antonio Bianchi - University of Florence
Dr Francesca Binacchi - University of Pisa
Prof Tarita Biver - University of Pisa
Dr Jeremy Brandel - University of Strasbourg/CNRS
Dr Clemente Bretti - University of Messina
Dr Axel Buchholz - Friedrich-Schiller-Universität Jena
Dr Péter Buglyó - University of Debrecen
Dr Natalia Busto Vázquez - Universidad de Burgos
Dr David Calin - Universitat de Lleida
Dr Rosita Cappai - Università degli studi di Cagliari
Dr Salvatore Cataldo - Università degli Studi di Palermo
Prof Isabel Cavaco - Universidade do Algarve
Dr Sílvia Chaves - Centro de Química Estrutural
Dr Rosalia Maria Cigala - University of Messina
Prof Encarna Companys - Av. Rovisco Pais 1049-001 Lisboa
Prof Guido Crisponi - Università degli studi di Cagliari
Dr Aleksandra Dimitrijevic - Vinca Institute of Nuclear Sciences
Dr Alicia Dominguez-Martin - University of Granada
Dr Orsolya Dömötör - University of Szeged
Dr Eva Anna Enyedy - University of Szeged, Faculty of Science and Informatics, Institute of Chemistry
Dr Gianluca Farine - Università degli Studi di Palermo
Dr Erika Ferrari - University of Modena and Reggio Emilia
Dr Mariana Ferreira - LAQV, REQUIMTE - Universidade do Porto
Dr Linda Földi-Bíró - University of Debrecen
Prof Eva Freisinger - University of Zurich
Prof Slobodan Gadzuric - University of Novi Sad, Faculty of Sciences
Dr Sofia Gama - University of Bialystok, Faculty of Chemistry
Prof Paula Gameiro - University Porto
Prof Begona Garcia - Universidad de Burgos
Prof Enrique García-España - University of Valencia
Dr Silvia Gentili - University of Parma
Dr Giuseppa Ida Grasso - University of Catania
Dr Darren Griffith - Royal College of Surgeons in Ireland
Prof Elzbieta Gumienna-Kontecka - University of Wrocław
Prof Josef Hamacek - University of Orléans/CNRS
Dr Aleksandra Hecel - University of Wrocław
Prof Petr Hermann - Charles University
Dr Olga Iranzo - Institut des Sciences Moléculaires de Marseille UMR CNRS 7313
Dr Anna Irto - University of Messina
Dr Aleksandra Jedynczuk - University of Wroclaw
Prof Dijana Jelić - University of Banja Luka, Faculty of Natural Sciences and Mathematics
Dr Ana Jocić - Vinca Institute of Nuclear Sciences
Mr Mateusz Kowalik - Jan Kochanowski Univeristy in Kielce
Prof Henryk Kozlowski - University of Wrocław
Ms Karolina Krzywoszynska - University of Wrocław
Dr Vojtěch Kubíček - Charles University, Faculty of Science
Prof Iwona Łakomska - Nicolaus Copernicus University in Toruń
Prof Jose Maria Leal Villalba - Universidad de Burgos
Dr Andreia Leite - Faculdade de Ciȇncias da Universidade do Porto
Dr Ivo Leito - University of Tartu
Dr Stephan Liebsch - Zschimmer & Schwarz Mohsdorf GmbH & Co. KG
Prof João Carlos Lima - Nova Univerity Lisbon
Prof Premysl Lubal - Masaryk University
Ms Francesca Macii - University of Pisa
Dr Slađana Marić - University of Belgrad
Dr Alvaro Martinez Camarena - Universitat de Valencia
Dr Joanna Masternak - Jan Kochanowski Univeristy in Kielce
Prof Andrea Melchior - Università degli Studi di Udine
Dr Michel Meyer - CNRS
Dr Rossella Migliore - University of Catania
Prof Demetrio Milea - Università degli Studi di Messina
Dr Adriana Miller - University of Wroclaw
Dr Andrzej Mular - University of Wroclaw
Dr Edyta Nalewajko-Sieliwonuk - University of Bialystok
Dr Raisa Nastas - Institute of Chemistry
Prof Valeria Marina Nurchi - Università degli studi di Cagliari
Dr Malgorzata Ostrowska - University of Wrocław
Dr Massimiliano Peana - University of Sassari
Ms Monica Perinelli - University of Zurich (UZH)
Prof Alberto Pettignano - Università degli Studi di Palermo
Prof Winfried Plass - Friedrich-Schiller-Universität Jena
Mr Slawomir Potocki - University of Wrocław
Prof Jaume Puy - Universitat de Lleida
Prof Arūnas Ramanavičius - State Scientific Research Institute Center for Physical Sciences and Technology
Prof Peter Rapta - Slovak University of Technology in Bratislava
Prof Maurizio Remelli - University of Ferrara
Prof Carlos Rey-Castro - Universitat de Lleida
Prof Laura Rodríguez Raurell - University of Barcelona
Dr Anna Rola - University of Wroclaw
Dr Magdalena Rowinska-Zyrek - University of Wrocław
Dr Urte Samukaite Bubniene - Vilnius University
Dr Martina Sanadar - University of Udine
Prof M. Amelia Santos - Instituto Superior Técnico, Universidade de Lisboa
Dr Matteo Savastano - Università degli Studi di Firenze
Prof Carmelo Sgarlata - Università degli Studi di Catania
Mr Filip Smrčka -
Prof Sigridur Suman - University of Iceland
Ms Jolanta Maria Swiatek-Kozlowska - University of Wrocław
Ms Agnieszka Szebesczyk - University of Wrocław
Prof Matteo Tegoni - University of Parma
Prof Alessio Terenzi - Università degli Studi di Palermo
Prof Marilena Tolazzi - Università degli Studi di Udine
Dr Ana Isabel Tomaz - Centro de Química Estrutural –Faculdade de Ciências
Ms Yuliya Toporivska - University of Wrocław
Prof Iztok Turel - University of Ljubljana
Prof Nikolay Tzvetkov - Institute of Molecular Biology “Roumen Tsanev”, Bulgarian Academy of Sciences
Prof Katalin Várnagy - University of Debrecen
Dr Daniele Veclani - University of Udine
Dr Danuta Witkowska - Opole University, Institute of Health Sciences
Dr Konstantina Yannakopoulou - National Center for Scientific Research "Demokritos"
Prof Emel Yildiz - Cukurova University
Dr Catalina Natalia Yilmaz - Romanian Academy
Prof Adnan Zahirovic - University of Sarajevo Faculty of Science
Mr Nikola Zdolšek - Vinca Institute of Nuclear Sciences

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