NECTAR for strong and/or multifunctional ligands, macromolecules, polyelectrolytes
Strong binding of metal ions (sequestration) and selectivity of binding are processes of outmost importance for several applications (e.g., chelation therapy, nuclear medicine, environmental remediation, metal recovery, water treatment). Strong binding can be operated by a large number of ligands (natural or synthetic) which all share the property of forming very stable complexes. The determination of corresponding thermodynamic equilibrium data is extremely difficult, and cannot be performed by classical approaches. In addition, complexes of some pre-organised ligands (e.g. those currently used in medicine) are formed very slowly, and kinetical aspects have to be considered to get correct thermodynamic data. Also, similar ligands which have limited structural differences often form complexes with the same metal ion that differ in stability by orders of magnitude. Therefore, the design of selective ligands requires a precise knowledge of structure-stability relationships.